:root {
  --ink: #17212b;
  --muted: #617080;
  --line: #d8dee5;
  --soft: #f4f7f9;
  --blue: #006699;
  --blue-dark: #064667;
  --cyan: #00a6c8;
  --green: #12805c;
  --red: #b03a3a;
  --amber: #956018;
  --panel: #ffffff;
  font-family: Inter, "Segoe UI", Arial, sans-serif;
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  color: var(--ink);
  background: #f8fafb;
}

.topbar {
  min-height: 68px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 24px;
  padding: 0 30px;
  border-bottom: 1px solid var(--line);
  background: #fff;
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  font-size: 24px;
  color: var(--blue-dark);
  font-weight: 700;
  text-decoration: none;
}

.brand:visited,
.brand:hover,
.brand:focus {
  color: var(--blue-dark);
  text-decoration: none;
}

.brand-mark {
  width: 36px;
  height: 36px;
  border: 5px solid var(--cyan);
  border-left-color: transparent;
  border-radius: 50%;
  display: inline-block;
  position: relative;
}

.brand-mark::after {
  content: "";
  position: absolute;
  width: 8px;
  height: 8px;
  border-radius: 50%;
  background: var(--blue);
  right: -5px;
  top: 2px;
  box-shadow: -20px 24px 0 #74b4ca, -5px 30px 0 var(--blue);
}

.nav {
  display: flex;
  align-items: center;
  gap: 24px;
  font-weight: 600;
}

.nav a {
  color: var(--blue-dark);
  text-decoration: none;
  border-bottom: 2px solid transparent;
  padding: 4px 0;
}

.nav a.active {
  border-bottom-color: var(--cyan);
}

.view-panel[hidden] {
  display: none;
}

main {
  max-width: 1500px;
  margin: 0 auto;
  padding: 28px 24px 44px;
}

.hero {
  min-height: 260px;
  display: grid;
  grid-template-columns: minmax(0, 1fr) 310px;
  gap: 24px;
  align-items: center;
  padding: 34px 40px;
  color: #fff;
  background:
    linear-gradient(125deg, rgba(0, 91, 132, 0.95), rgba(6, 70, 103, 0.98)),
    radial-gradient(circle at 16% 22%, rgba(255, 255, 255, 0.2), transparent 28%);
  border-radius: 8px;
}

.hero h1 {
  margin: 8px 0 12px;
  font-size: 42px;
  line-height: 1.08;
  letter-spacing: 0;
}

.hero p {
  max-width: 680px;
  margin: 0;
  color: rgba(255, 255, 255, 0.9);
  font-size: 17px;
  line-height: 1.55;
}

.hero-copy p:not(.eyebrow) {
  max-width: 980px;
  white-space: nowrap;
}

.eyebrow,
.label {
  margin: 0 0 6px;
  color: var(--cyan);
  font-size: 13px;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  font-weight: 800;
}

.hero .eyebrow {
  color: #aeeaff;
}

.molecule-panel {
  height: 185px;
  position: relative;
}

.molecule-panel::before,
.molecule-panel::after {
  content: "";
  position: absolute;
  inset: 36px 18px auto;
  height: 2px;
  background: rgba(255, 255, 255, 0.42);
  transform: rotate(-18deg);
}

.molecule-panel::after {
  inset: 112px 28px auto 42px;
  transform: rotate(18deg);
}

.molecule-panel span {
  width: 42px;
  height: 42px;
  border-radius: 50%;
  position: absolute;
  background: #fff;
  box-shadow: 0 12px 28px rgba(0, 0, 0, 0.16);
}

.molecule-panel span:nth-child(1) { left: 24px; top: 28px; background: #d9f7ff; }
.molecule-panel span:nth-child(2) { left: 120px; top: 12px; background: #ffffff; }
.molecule-panel span:nth-child(3) { left: 216px; top: 70px; background: #8be1f3; }
.molecule-panel span:nth-child(4) { left: 84px; top: 124px; background: #ffffff; }
.molecule-panel span:nth-child(5) { left: 196px; top: 135px; background: #d9f7ff; }

.workspace {
  display: block;
  margin-top: 18px;
}

.input-panel,
.summary-panel,
.results-section,
.threshold-section {
  background: var(--panel);
  border: 1px solid var(--line);
  border-radius: 8px;
}

.input-panel,
.summary-panel {
  padding: 18px 22px;
}

.panel-heading,
.section-heading {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 16px;
  margin-bottom: 14px;
}

h2 {
  margin: 0;
  font-size: 22px;
  letter-spacing: 0;
}

textarea {
  width: 100%;
  height: 230px;
  min-height: 230px;
  resize: vertical;
  overflow: auto;
  border: 1px solid #bfc9d3;
  border-radius: 6px;
  padding: 14px;
  color: var(--ink);
  font: 15px/1.5 Consolas, "Courier New", monospace;
  background: #fbfdfe;
}

textarea:focus,
input:focus,
button:focus-visible {
  outline: 3px solid rgba(0, 166, 200, 0.26);
  outline-offset: 2px;
}

.file-row,
.controls,
.download-row {
  display: flex;
  align-items: center;
  gap: 12px;
  flex-wrap: wrap;
  margin-top: 14px;
}

.file-picker {
  display: inline-flex;
  align-items: center;
  min-height: 40px;
  padding: 0 14px;
  border: 1px solid var(--blue);
  border-radius: 6px;
  color: var(--blue-dark);
  font-weight: 700;
  cursor: pointer;
}

.file-picker input {
  display: none;
}

.chain-select {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 700;
}

.chain-select select {
  min-height: 40px;
  border: 1px solid #c5d0d8;
  border-radius: 6px;
  padding: 0 10px;
  color: var(--blue-dark);
  background: #fff;
  font-weight: 700;
}

#fileName,
.hint {
  color: var(--muted);
  font-size: 13px;
}

button {
  border: 0;
  border-radius: 6px;
  min-height: 42px;
  padding: 0 16px;
  font-weight: 800;
  cursor: pointer;
}

button:disabled {
  cursor: not-allowed;
  opacity: 0.48;
}

.primary-button {
  color: #fff;
  background: var(--blue);
}

.secondary-button {
  color: var(--blue-dark);
  background: #e8f4f8;
  border: 1px solid #b7dce8;
}

.ghost-button {
  color: var(--blue-dark);
  background: transparent;
  border: 1px solid var(--line);
}

.summary-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 8px;
  margin: 16px 0 12px;
}

.result-summary-panel {
  margin-bottom: 18px;
}

.summary-grid div {
  min-height: 58px;
  padding: 10px 12px;
  border: 1px solid #dce5eb;
  border-radius: 6px;
  background: var(--soft);
}

.summary-grid strong {
  display: block;
  font-size: 24px;
  line-height: 1;
  color: var(--blue-dark);
}

.summary-grid span {
  color: var(--muted);
  font-size: 12px;
  font-weight: 700;
}

.mini-report {
  margin-top: 12px;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.5;
}

.results-section {
  margin-top: 18px;
  padding: 20px;
}

.result-download-panel {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
  padding: 0 0 18px;
  margin-bottom: 18px;
  border-bottom: 1px solid var(--line);
}

#tableFilter {
  min-height: 38px;
  width: min(260px, 100%);
  border: 1px solid #c5d0d8;
  border-radius: 6px;
  padding: 0 12px;
}

.table-wrap {
  overflow-x: auto;
  border: 1px solid var(--line);
  border-radius: 6px;
}

table {
  width: 100%;
  border-collapse: collapse;
  min-width: 2180px;
  font-size: 14px;
}

th,
td {
  padding: 11px 12px;
  border-bottom: 1px solid #e4e9ee;
  text-align: left;
  vertical-align: top;
}

th {
  background: #f0f5f7;
  color: #34495a;
  font-size: 12px;
  text-transform: uppercase;
  letter-spacing: 0.04em;
}

tbody tr:hover {
  background: #f8fcfd;
}

.seq-cell {
  max-width: 260px;
  word-break: break-all;
  font-family: Consolas, "Courier New", monospace;
}

.status {
  display: inline-flex;
  align-items: center;
  min-height: 24px;
  border-radius: 999px;
  padding: 0 10px;
  font-size: 12px;
  font-weight: 900;
}

.status.pass {
  color: var(--green);
  background: #e5f6ef;
}

.status.fail {
  color: var(--red);
  background: #fdecec;
}

.empty-row td {
  color: var(--muted);
  text-align: center;
  padding: 24px;
}

.threshold-section {
  margin-top: 18px;
  padding: 18px 20px;
}

.threshold-intro {
  max-width: none;
  margin-bottom: 18px;
}

.threshold-intro h2 {
  margin-bottom: 8px;
}

.threshold-intro p:not(.label) {
  margin: 0;
  color: var(--muted);
  line-height: 1.45;
}

.scoring-model {
  margin-bottom: 18px;
  padding: 16px;
  border: 1px solid #c9e4ec;
  border-radius: 6px;
  background: #edf6f8;
}

.scoring-model h3 {
  margin: 0 0 8px;
  font-size: 18px;
}

.scoring-model p {
  margin: 0 0 12px;
  color: var(--muted);
  line-height: 1.5;
}

.score-weights {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
}

.score-weights span {
  padding: 7px 9px;
  border: 1px solid #b7dce8;
  border-radius: 6px;
  background: #fff;
  color: var(--blue-dark);
  font-size: 13px;
  font-weight: 800;
}

.results-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
  padding: 22px 0 16px;
}

.results-header h1 {
  margin: 0;
  font-size: 34px;
  letter-spacing: 0;
}

.results-actions {
  display: flex;
  gap: 12px;
  flex-wrap: wrap;
}

.summary-strip {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 14px;
  margin-bottom: 18px;
}

.summary-strip div {
  min-height: 88px;
  padding: 16px;
  border: 1px solid #dce5eb;
  border-radius: 8px;
  background: #fff;
}

.summary-strip strong {
  display: block;
  color: var(--blue-dark);
  font-size: 32px;
}

.summary-strip span {
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
}

.standalone-results {
  margin-top: 0;
}

.thresholds {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
}

.threshold-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 12px;
}

.threshold-grid div {
  padding: 14px;
  border: 1px solid #dce5eb;
  border-radius: 6px;
  background: var(--soft);
}

.threshold-grid strong {
  display: block;
  margin-bottom: 5px;
  color: var(--blue-dark);
}

.threshold-grid span {
  display: inline-block;
  margin-bottom: 8px;
  color: var(--ink);
  font-weight: 800;
}

.threshold-grid p {
  margin: 0;
  color: var(--muted);
  font-size: 13px;
  line-height: 1.45;
}

.references {
  margin-top: 20px;
  padding-top: 18px;
  border-top: 1px solid var(--line);
}

.references h3 {
  margin: 0 0 10px;
  font-size: 18px;
}

.references ol {
  margin: 0 0 4px;
  padding-left: 22px;
  color: var(--muted);
  line-height: 1.7;
}

.references a {
  color: var(--blue-dark);
  font-weight: 700;
  text-decoration: none;
}

.references a:hover {
  text-decoration: none;
}

.thresholds span {
  padding: 8px 10px;
  background: #edf6f8;
  border: 1px solid #c9e4ec;
  border-radius: 6px;
  color: #31566a;
  font-weight: 700;
  font-size: 13px;
}

.site-footer {
  max-width: 1500px;
  margin: 0 auto;
  padding: 20px 24px 26px;
  color: #40546a;
  text-align: center;
  font-size: 14px;
  line-height: 1.35;
}

.site-footer p {
  margin: 4px 0;
}

.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  white-space: nowrap;
  border: 0;
}

@media (max-width: 1180px) {
  .hero-copy p:not(.eyebrow) {
    white-space: normal;
  }
}

@media (max-width: 860px) {
  .topbar,
  .panel-heading,
  .section-heading {
    align-items: flex-start;
    flex-direction: column;
  }

  .hero,
  .workspace,
  .summary-strip,
  .threshold-grid {
    grid-template-columns: 1fr;
  }

  .summary-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .results-header {
    align-items: flex-start;
    flex-direction: column;
  }

  .result-download-panel {
    align-items: flex-start;
    flex-direction: column;
  }

  .hero {
    padding: 26px;
  }

  .hero h1 {
    font-size: 32px;
  }

  .hero-copy p:not(.eyebrow) {
    white-space: normal;
  }

  .molecule-panel {
    display: none;
  }
}